In Vitro ADME/Tox

  • Compound Purity, Solubility, Dissolution and Chemical Stability

  • Caco-2 Permeability
  • Metabolic Stability
  • CYP450 Inhibition
  • CYP450 Induction
  • CYP450 Phenotyping
  • UGT Inhibition
  • UGT Phenotyping
  • Uptake Transporter Inhibition
  • Uptake Transporter Phenotyping
  • Efflux Transporter Inhibition
  • Efflux Transporter Phenotyping
  • Additional Drug-Metabolizing Enzyme Phenotyping (FMOs, MAOs, AOs, ALDH, ADH)
  • Plasma or Whole Blood Stability
  • Blood-to-Plasma Partitioning
  • Plasma Protein Binding
  • Tissue Binding
  • Drug Metabolite Profiling and Structural Identification
  • GSH Trapping for Reactive Metabolites Formation
  • Cytotoxicity
  • Hemolysis
  • ‚Äč‚ÄčImmunogenicity

In Vivo PK

  • Standard PK

  • Formulation Screening PK
  • Salt Form Screening PK
  • Food-Drug Interaction PK
  • Dose Linearity PK
  • Renal Excretion
  • Biliary Excretion
  • Tissue Distribution

Bioanalysis of Samples

  • Biofluid (Plasma, Serum, Blood, Urine, and Bile) Sample Analysis by LC-MS/MS

  • Tissue Sample Analysis by LC-MS/MS
  • Determination of Sample Concentrations in Biological or Non-Biological Media

Formulation Development

  • IV Formulation for Drug Discovery

  • Oral Formulation for Drug Discovery
  • IV Formulation for Dose-Range-Finding or GLP Toxicology Studies
  • Oral Formulation for Dose-Range-Finding or GLP Toxicology Studies
  • Drug Stability in Formulations